Immune memory, from either infection or immunization, is the source of long-term protective immunity. Antibodies are a key component of immune memory that can provide protection. The spike protein is the focus of most COVID-19 vaccines. Antibody responses to the spike protein and other viral proteins can be used as correlates of immunity.
The Immunity EpitoGen® test is designed to detect IgG antibody responses to the vaccine target spike protein, the mutant spike containing prevalent mutations, and other non-spike SARS-CoV-2 proteins. The test can evaluate how effective the vaccine-induced protection will be in combating SARS-CoV-2 and emerging SARS-CoV-2 variants. Moreover, the test evaluates antibody response to non-spike SARS-CoV-2 proteins and their corresponding mutants. Therefore, the test can also differentiate between immunisation-induced immunity and infection-induced immunity.
Immunity EpitoGen® can be used before & after SARS-CoV-2 infection and/or vaccination to provide a readout of immunity against further infection by the reference strain or mutated variants.
Unique points to EpitoGen Immunity:
1) A readout of Spike specific antibodies post vaccination/infection to evaluate immune memory;
2) Evaluate protection against SARS-CoV-2 variants including the Indian, South African and UK variants (16 prevalent spike mutations);
3) Utilise four non-spike antigens & corresponding mutants (N, M, ORF3a and ORF7a, 29 non-spike prevalent mutations);
4) Differentiate between vaccine-induced and infection-induced immunity.
