Flagellins are the structural components of the flagellum, a locomotory organ that enables bacterial motility. Usually, flagellins are viewed as virulence factors employed by bacteria to invade host cells.
But recent research has shown that flagellins are a potent immune activator, shaping both the innate and adaptive arms of immunity during microbial infections. Consequently, flagellins have been utilised as adjuvants, anti-tumour and radioprotective agents. The incorporation of flagellins as an adjuvants and/or in combating tumour growth and radiation-associated tissue damage has shown tremendous potential with many vaccines successfully entering into clinical trials.
We have generated a panel of over 30 bioactive flagellins to a broad range of bacterial species, all of which to be made available to forward research and vaccine development.