Flagellins are the structural components of the flagellum, a locomotory organ that enables bacterial motility. Usually, flagellins are viewed as virulence factors employed by bacteria to invade host cells.

But recent research has shown that flagellins are a potent immune activator, shaping both the innate and adaptive arms of immunity during microbial infections. Consequently, flagellins have been utilised as adjuvants, anti-tumour and radioprotective agents. The incorporation of flagellins as an adjuvants and/or in combating tumour growth and radiation-associated tissue damage has shown tremendous potential with many vaccines successfully entering into clinical trials.

We have generated a panel of over 30 bioactive flagellins to a broad range of bacterial species, all of which to be made available to forward research and vaccine development.

Piscirickettsia salmonis Pseudomonas syringae pv. pisi
Listeria monocytogenes Legionella pneumophila
Vibrio anguillarum Edwardsiella tarda
Aeromonas hydrophila Pseudomonas aeruginosa
Pseudomonas putida Pseudomonas putida
Bacillus cereus Yersinia rucker
Edwardsiella ictalurid Bordetella pertussis
Aliivibrio salmonicida Salmonella typhimurium